Rebooting the series from scratch.
There are a few things noticeably different from the Toby McGuire Spiderman.
This Spidey will have the normal web-shooters. Not the organic shooters like in the movies before.
The preview showed him saying goodbye to his folks before they died, in an effort to show his detached emotional point of view.
And it's looks like it might be a radioactive spider rather than the genetically modified spider that bit him.
As to see if it's theater worthy yet: The jury is still out.